Semax (Intranasal) protocol

Standard

2–4 sprays

200–400 mcg · Daily AM

1–2 sprays per nostril, alternating sides. 100 µL @ 1 mg/mL = 100 mcg per spray.

Higher

6.0 sprays

600 mcg · Daily AM

3 sprays per nostril, alternating sides. Or split AM + early afternoon to reduce nasal irritation.

Off

1–2 weeks

Tolerance prevention. 5-day-on / 2-day-off variant also community-standard.

Phase	How often	Dose	Units	Notes
Standard	Daily AM	200–400 mcg	2–4 sprays	1–2 sprays per nostril, alternating sides. 100 µL @ 1 mg/mL = 100 mcg per spray.
Higher	Daily AM	600 mcg	6.0 sprays	3 sprays per nostril, alternating sides. Or split AM + early afternoon to reduce nasal irritation.
Off	1–2 weeks	–	–	Tolerance prevention. 5-day-on / 2-day-off variant also community-standard.

Cycle & timing

Cycle: 2–4 week blocks, 1–2 weeks off.

Timing: AM intranasal, calibrate sprays with the supplier’s nasal pump (standard 100 µL per actuation) before clinical use.

Where: Intranasal: 1–2 sprays per nostril, alternating sides each dose. Use a calibrated nasal pump (100 µL/spray, 100 mcg per spray at this recon) and tilt head slightly back during instillation. For SubQ injection, see the Semax page.

What to expect

Mental clarity and focus often within hours of first dose. Sustained cognitive enhancement builds over 2–4 weeks. Brief headache in days 1–3 is normal.

How much to buy

For 4-wk @ 600 mcg × 7/wk:

4

× 5mg vials

2

× 10mg vials

Men & women

Unisex nootropic / neuroprotective (intranasal), dose by protocol, no sex effect. Avoid in pregnancy.

Recommended mixes

Vial	Water	Strength
5 mg	5 mL sterile saline	1 mg/mL
10 mg	10 mL sterile saline	1 mg/mL

5 mg: 1 spray = 100 mcg (100 µL)

10 mg: 1 spray = 100 mcg (100 µL) (10 mL nasal spray bottle)

Storage

PowderFreeze-dried: -4°F.
MixedReconstituted in saline: 36–46°F, use within 21 days.
Toss itDiscard if cloudy or particulate.

Side effects

Headache (first 1–3 days, resolves). Irritability if stacked with stimulants.

Labs

Compound-specific: CBC + CMP baseline; no compound-specific markers routinely required

What these labs mean →

Patient education

Aseptic technique: alcohol swab the vial septum and the injection site, use a single-use sterile needle for every injection, never share vials or needles between people. Sharps disposal in an FDA-cleared sharps container, never household trash. Cold chain: if a refrigerated peptide reaches room temperature for more than the labeled stability window, discard it. Mark the date of first puncture on every multi-dose vial. Inspect every vial before injection: clear solution (unless labeled otherwise), no particulates, no cloudiness, no color change. Rotate injection sites to avoid lipoatrophy, induration, and infection. Carry a record of what you’re injecting if you need emergency care.

These apply on top of the universal safety rules.

Pairs well with

Selank

anxiolytic + cognitive synergy

Selank

BPC-157

neurorepair

BPC-157

Alpha-GPC or Citicoline

choline source prevents headache

Avoid with

MAOIs

Active psychosis / mania

Can Semax (Intranasal) + Selank share a syringe?

Intranasal stays in its spray. Intranasal Selank / Semax aren't injected, so they're never drawn into a syringe. Different routes never combine.

What it does

Approved pharmaceutical in Russia and Ukraine – and stroke recovery. analog stimulating BDNF/NGF synthesis, upregulating serotonin/dopamine receptors, and activating PDGF for neuroprotection.

Evidence

Russian-approved (stroke/cognition); no Western RCT.

Approved drug

There is no FDA-approved cognitive enhancer, no drug is approved for boosting focus or memory in healthy people (stimulants are approved only for ADHD/narcolepsy). Semax’s Russian approval does not apply in the US.

References

PubMed thepeptidereport

From the guide, page 86.