Cagrilintide protocol

Check your units. The units in this table assume 3.33 mg/mL, but the guide's recommended mix makes 5 mg/mL. If you mix it that way, your units will be different. Use the calculator to get the right draw for your vial.

Titration

Weeks 1–4

7.5u

0.25 mg · Once weekly

Titrate slowly, nausea is dose-dependent.

Weeks 5–8

15u

0.5 mg · Once weekly

Weeks 9–12

30u

1.0 mg · Once weekly

Weeks 13–16

51u

1.7 mg · Once weekly

Week 17+

72u

2.4 mg · Once weekly

Research-target maintenance. Do not exceed ~4.5 mg/week.

Phase	How often	Dose	Units	Notes
Weeks 1–4	Once weekly	0.25 mg	7.5u	Titrate slowly, nausea is dose-dependent.
Weeks 5–8	Once weekly	0.5 mg	15u
Weeks 9–12	Once weekly	1.0 mg	30u
Weeks 13–16	Once weekly	1.7 mg	51u
Week 17+	Once weekly	2.4 mg	72u	Research-target maintenance. Do not exceed ~4.5 mg/week.

Phases are 4 wks each. Units column is labelled “Units (3.33 mg/mL)” on the page. Stack: commonly combined with semaglutide (CagriSema), titrate the two together and expect stronger GI effects.

Cycle & timing

Cycle: Titrate over 16–20 weeks to the 2.4 mg maintenance dose; escalate only when the current dose is well tolerated.

Timing: Same day each week, any time, with or without food. Rotate injection sites.

Where: SubQ, abdomen/thigh. Rotate.

What to expect

Earlier satiety and smaller portions within weeks; steady weight loss over months (strongest with a GLP-1).

How much to buy

For 16-wk titration to 2.4 mg/wk:

7

× 2mg vials

3

× 5mg vials

2

× 10mg vials

Men & women

Men: In men, excess fat lowers testosterone; GLP-1 raises testosterone, SHBG and gonadotropins as weight drops, improves sperm and erectile function, and preserves fertility (unlike TRT).

Women: Women lose more than men at the same dose but report more GI (start lower). In PCOS they improve cycles, lower free testosterone and raise ovulation; a real unplanned-pregnancy risk. Stop before conceiving.

Dilution calculator

Set to the guide's typical mix for Cagrilintide. Change anything to see where to draw.

Vial size

BAC water added

Dose you want

Draw to

48u

Volume

0.48 mL

Strength

5 mg/mL

Doses per vial

2

Assumes a U-100 insulin syringe (100 units = 1 mL). Double-check against the compound's page before you draw.

Recommended mixes

Vial	Water	Strength
2 mg	0.4 mL	5 mg/mL
5 mg	1 mL	5 mg/mL
10 mg	2 mL	5 mg/mL

2 mg: 1 unit = 0.05 mg (50 mcg)

Storage

PowderFreeze-dried: -4°F.
MixedReconstituted: 36–46°F, up to 30 days.

Don't use if: Pregnancy and lactation · Active or severe gastroparesis · Hypersensitivity to amylin analogs · Type 1 diabetes / on insulin without supervision (hypoglycemia risk)

Stop if you notice

Severe or persistent vomiting / inability to stay hydrated
Severe abdominal pain
Signs of hypoglycemia when stacked with insulin/sulfonylureas
Pregnancy

Side effects

Nausea, reduced appetite, constipation/diarrhea, injection-site reactions. GI effects are dose-dependent and ease with slow titration.

Drug interactions

Insulin / sulfonylureas: additive hypoglycemia, reduce those doses, monitor glucose. Oral drugs with narrow timing (e.g. some antibiotics, levothyroxine): delayed emptying alters absorption. Other GLP-1 / amylin agents: additive GI and appetite effects.

Labs

Fasting glucose / HbA1c (baseline + periodic), especially if diabetic. Renal function if significant vomiting/diarrhea. Weight, blood pressure, heart rate trend. Out of range? Rising glucose/HbA1c = creeping toward diabetes (recheck, tighten diet); falling eGFR = kidney strain, usually dehydration (hydrate, hold).

What these labs mean →

Warnings

Hypoglycemia risk when combined with insulin or sulfonylureas. Marked GI effects (nausea, vomiting); titrate slowly. Dehydration from GI losses, can stress the kidneys. Research compound, no long-term human safety data outside trials.

Patient education

Go slow on titration, rushing the dose causes most of the nausea. Stop and seek care for severe abdominal pain or persistent vomiting.

These apply on top of the universal safety rules.

Pairs well with

Semaglutide / Tirzepatide / Retatrutide

amylin + incretin synergy

Semaglutide Tirzepatide Retatrutide

Lipo-C / L-Carnitine

metabolic support

LC120 L-Carnitine

Avoid with

Active gastroparesis

Pregnancy

Can Cagrilintide + Semaglutide share a syringe?

Never stack two GLP-1s. Stacking multiplies nausea and hypoglycemia risk. Only engineered combos (like CagriSema) pair them.

What it does

Cagrilintide is a long-acting amylin analog. It signals satiety, slows gastric emptying, and reduces food intake through a mechanism complementary to GLP-1 drugs; which is why amylin + GLP-1 stacks outperform either alone. Once-weekly dosing.

Approved drug

Pramlintide (Symlin) is the approved amylin drug, but for diabetes, not weight loss. For weight loss: semaglutide or tirzepatide.

References

researchdosing peptidedosages PubMed thepeptidereport GLP-1 sex differences Jensterle 2020

From the guide, page 25.