Epithalon protocol

Standard

Days 1–10

25–50u

5–10 mg · Daily or twice daily

10 mg/day × 10 days standard.

Days 1–20

25u

5 mg · Daily

Extended course.

Repeat

Seasonal 2–3×/year

4–6 months apart.

Phase	How often	Dose	Units	Notes
Days 1–10	Daily or twice daily	5–10 mg	25–50u	10 mg/day × 10 days standard.
Days 1–20	Daily	5 mg	25u	Extended course.
Repeat	Seasonal 2–3×/year	–	–	4–6 months apart.

Cycle & timing

Cycle: 10–20 day courses, 2–3× per year.

Timing: 10-day course, daily SubQ pre-bed; repeat 2×/year.

Where: SubQ abdomen or outer thigh.

What to expect

Improved sleep and circadian normalisation first (1–2 weeks). Gradual energy and immune improvement over 2–3 annual courses. Benefits compound over years.

How much to buy

For 10-day course @ 10 mg/day = 100 mg:

10

× 10mg vials

2

× 50mg vials

Men & women

Unisex bioregulator (pineal / telomerase), short courses, same dose in both sexes. Avoid in pregnancy.

Dilution calculator

Set to the guide's typical mix for Epithalon. Change anything to see where to draw.

Vial size

BAC water added

Dose you want

Draw to

50u

Volume

0.50 mL

Strength

20 mg/mL

Doses per vial

1

Assumes a U-100 insulin syringe (100 units = 1 mL). Double-check against the compound's page before you draw.

Recommended mixes

Vial	Water	Strength
10 mg	0.50 mL	20 mg/mL
50 mg	2.5 mL	20 mg/mL

10 mg: 1 unit = 0.20 mg

Storage

PowderFreeze-dried: -4°F.
MixedReconstituted: 36–46°F, use within 30 days. Protect from light.

Don't use if: Pregnancy and lactation (no safety data) · Active malignancy (theoretical concerns; no human RCT data on cancer risk) · Children and adolescents (no pediatric data outside Russian clinical use)

Side effects

Generally very well tolerated. Rare: injection-site irritation.

Labs

Compound-specific: Salivary melatonin at 9 PM (baseline + after 20-day course). No specific markers. Baseline CBC + CMP; target-tissue labs (salivary melatonin for Epithalon).

What these labs mean →

Warnings

Most clinical evidence is Russian/CIS, much doesn't meet ICH-GCP standards. No FDA approval; not regulated as drugs in the US. Limited human safety data outside the Khavinson research group. Long-term safety beyond 5 years of cyclic use not established. Most-studied of the Khavinson peptides but still no Western RCTs. PCAC RECOMMENDED it (as "epitalon") for the 503A bulks list, 7–5 (Jul 2026; advisory, non-binding).

Patient education

Bioregulators, research use only in most jurisdictions. Russian use approved; US/EU off-label or unapproved. Quality varies, request COA for each lot. 10-day courses, 2–3×/year; continuous dosing isn't supported.

These apply on top of the universal safety rules.

Pairs well with

Thymosin Alpha-1

immune amplification

Thymosin Alpha-1

DSIP

sleep architecture, complementary circadian effect

DSIP

Avoid with

Active malignancy

Pregnancy / nursing

Can Epithalon + Thymosin Alpha-1 share a syringe?

Can share a syringe. Both are water-based. Combine them if you dose on the same schedule and site.

What it does

Telomerase activation reported in rodent studies.

Stimulates telomerase (hTERT) expression. Normalises pineal. Developed by Vladimir Khavinson.

Won't dissolve?

Epithalon is a small water-loving peptide and should clear readily in BAC water. If a vial clouds or clumps, let the powder reach room temperature and roll gently (never shake). Still cloudy, community practice is a few drops of 0.6% acetic acid first, then top up with BAC water. Needing acid is a lot-quality signal (request a COA), not the normal method; unlike IGF-1 LR3, where acetic acid is genuinely required.

Evidence

Telomerase effect shown in human cell lines + animals; clinical data is Russian/CIS, no Western RCT.

References

perfectb researchdosing peptidedosages PubMed thepeptidereport

From the guide, page 32.