Hexarelin protocol

Standard

Weeks 1–6

5u

100 mcg · 1–2×/day

Working dose. ~1 mcg/kg saturates; do not chase higher. Fasted.

Off

6–8 weeks

Longer off than other GHRPs, receptors need more time to re-sensitize.

Phase	How often	Dose	Units	Notes
Weeks 1–6	1–2×/day	100 mcg	5u	Working dose. ~1 mcg/kg saturates; do not chase higher. Fasted.
Off	6–8 weeks	–	–	Longer off than other GHRPs, receptors need more time to re-sensitize.

Units column is for 2 mg/mL.

Cycle & timing

Cycle: 4–6 weeks on / 6–8 weeks off (shorter on, longer off than other GHRPs). Running it longer cuts response by 45%+ as receptors downregulate.

Timing: Empty stomach, AM and/or pre-bed.

Where: SubQ, abdomen. Rotate.

What to expect

Fast, strong GH response early in the cycle; benefit tapers as receptors desensitize; hence short cycles. Minimal appetite vs GHRP-6.

How much to buy

For 6-wk @ 100 mcg × 2/day:

5

× 2mg vials

2

× 5mg vials

Men & women

Men: Men overshoot the IGF-1 ceiling more easily (aim mid-normal). High prolactin from GHRPs lowers libido and testosterone in men, switch to a clean option if it climbs.

Women: Women are less responsive to GH (need more), and these ghrelin-types give a bigger GH bump in women; but they raise prolactin, which can disrupt the cycle/ovulation (watch for missed periods). Oral estrogen also blunts IGF-1.

Dilution calculator

Set to the guide's typical mix for Hexarelin. Change anything to see where to draw.

Vial size

BAC water added

Dose you want

Draw to

5u

Volume

0.05 mL

Strength

2 mg/mL

Doses per vial

20

Assumes a U-100 insulin syringe (100 units = 1 mL). Double-check against the compound's page before you draw.

Recommended mixes

Vial	Water	Strength
2 mg	1 mL	2 mg/mL
5 mg	2.5 mL	2 mg/mL

2 mg: 1 unit = 0.02 mg (20 mcg)

Storage

PowderFreeze-dried: -4°F.
MixedReconstituted: 36–46°F, up to 6 weeks.

Don't use if: Active malignancy of any kind (GH/IGF-1 can promote tumor growth) · Severe diabetic retinopathy · Acute critical illness (per somatropin label) · Pregnancy and lactation

Stop if you notice

Response clearly fading (expected, end the cycle and take the full off period)
Fasting glucose rises >20 mg/dL above baseline
IGF-1 above upper limit of normal for age
New joint pain, carpal tunnel, or vision changes

Side effects

Flushing, water retention, mild cortisol/prolactin rise. Diminishing response is the main practical limit.

Drug interactions

Glucocorticoids: blunt GH response. Insulin / antidiabetics: GH worsens insulin resistance, monitor glucose. Levothyroxine: GH lowers free T4, recheck TSH/fT4 quarterly. Oral estrogens: blunt GH-stimulated IGF-1.

Labs

IGF-1 (baseline + end of the short cycle). Fasting glucose / HbA1c (baseline + end). Prolactin if symptomatic. Age-appropriate cancer screening before starting. Out of range? IGF-1 above your age range = too much growth signal (feeds hidden cancer, enlarges organs) → drop the dose; rising glucose/HbA1c = sugar creeping up.

What these labs mean →

Warnings

Fastest receptor desensitization of any GHRP, short cycles are mandatory, not optional. Cortisol and prolactin elevation. Insulin resistance with sustained use. Fluid retention, carpal tunnel, joint pain. IGF-1 elevation: theoretical malignancy promotion beyond physiological ranges.

Patient education

Treat this as a short-cycle tool, it desensitizes faster than any other GHRP. Don't increase the dose to fight fading response; take the off period instead. Fasted dosing; protect sleep. Not for use during active malignancy or pregnancy; report new lumps or vision changes.

These apply on top of the universal safety rules.

Pairs well with

CJC-1295 (No DAC) / Sermorelin

GHRH synergy for the short cycle

CJC-1295 (No DAC) Sermorelin

Ipamorelin

rotate to after the hexarelin block

Ipamorelin

Avoid with

Active malignancy

Severe insulin resistance

Continuous / long-term use

desensitization

Stacking with other GHRPs simultaneously

Can Hexarelin + CJC-1295 (No DAC) share a syringe?

Mix freely: the classic GH pair. One GHRH primes the pituitary and one GHRP triggers a bigger pulse. Same solvent, pre-bed, empty stomach.

What it does

Somatropin (HGH) is approved for growth-hormone deficiency and tesamorelin (Egrifta) for HIV lipodystrophy. Secretagogues like this one are off-label.

Hexarelin is a highly potent GHS-R1a agonist with the strongest GH-releasing punch of the GHRPs and minimal appetite effect. Its high binding affinity drives the fastest receptor desensitization of any GHRP, so its window of usefulness is short. Mild cortisol/prolactin rise; some cardioprotective signaling in research.

Saturation

~1 mcg/kg, higher doses accelerate desensitization without more GH.

References

researchdosing peptidedosages PubMed thepeptidereport Span 2000 Weissberger 1991

From the guide, page 40.