Mazdutide
Another GLP-1 + glucagon dual agonist, like survodutide, but generally smoother on the stomach. Curbs appetite and nudges up energy expenditure.
Typical dose
6 mg
120u, Once weekly
Cycle
4-step titration over ~12–16 weeks to 6…
Timing
Same day each week, any time
Where
SubQ, abdomen/thigh
Standard titration (4 wks each)
Weeks 1–4
30u1.5 mg · Once weekly
Start here; smoother GI profile than survodutide.
Weeks 5–8
60u3 mg · Once weekly
Weeks 9–12
90u4.5 mg · Once weekly
Week 13+
120u6 mg · Once weekly
Maintenance. Many cap at 4–6 mg, especially if stacked. 120u is more than a standard 100-unit syringe holds: split it into two 60u shots.
Units at 5 mg/mL. Still raises heart rate via glucagon agonism, monitor.
Cycle & timing
Cycle: 4-step titration over ~12–16 weeks to 6 mg/week maintenance; each step lasts 4 weeks.
Timing: Same day each week, any time.
Where: SubQ, abdomen/thigh. Rotate.
What to expect
Appetite suppression plus a metabolic-rate effect; steady weight loss over months. Investigational outside its approval region.
How much to buy
For 16-wk titration to 6 mg/wk:
6
× 10mg vials
Men & women
Men: In men, excess fat lowers testosterone; GLP-1 raises total testosterone, SHBG and gonadotropins as weight drops, and improves sperm and erectile function; and preserves fertility, unlike TRT (which suppresses sperm).
Women: Women lose more than men at the same dose but report more GI (start lower). In PCOS they improve cycles, lower free testosterone and raise ovulation; a real unplanned-pregnancy risk. Stop before conceiving.