GHRP-2 protocol · PepGuide

Check your units. The units in this table assume 2 mg/mL, but the guide's recommended mix makes 5 mg/mL. If you mix it that way, your units will be different. Use the calculator to get the right draw for your vial.

Standard

Weeks 1–2

5u

100 mcg · 2×/day

AM fasted + pre-bed. Start low; assess flushing and tolerance.

Weeks 3–12

10u

200 mcg · 2–3×/day

Working dose. ~1 mcg/kg per dose is the saturating range, more raises cortisol/prolactin without more GH.

Off

4 weeks

Prevents ghrelin-receptor downregulation.

Phase	How often	Dose	Units	Notes
Weeks 1–2	2×/day	100 mcg	5u	AM fasted + pre-bed. Start low; assess flushing and tolerance.
Weeks 3–12	2–3×/day	200 mcg	10u	Working dose. ~1 mcg/kg per dose is the saturating range, more raises cortisol/prolactin without more GH.
Off	4 weeks	–	–	Prevents ghrelin-receptor downregulation.

Units column is labelled "Units (2 mg/mL)" in the source.

Cycle & timing

Cycle: 8–12 weeks on / 4 weeks off.

Timing: Empty stomach, no food 30 min after, ideally 2–3 h since last meal. Carbs/fats blunt the pulse. Pair each dose with a GHRH for synergy.

Where: SubQ, abdomen. Rotate.

What to expect

Improved sleep and recovery within 1–2 weeks; body-composition changes over 8–12 weeks. Strongest as part of a GHRH + GHRP stack.

How much to buy

For 12-wk @ 200 mcg × 2/day:

7

× 5mg vials

4

× 10mg vials

3

× 15mg vials

Men & women

Men: Men overshoot the IGF-1 ceiling more easily (aim mid-normal); high prolactin lowers libido and testosterone, switch to a cleaner option if it climbs.

Women: Women need more GH but get a bigger bump from ghrelin-types, though these raise prolactin, which can disrupt cycles/ovulation (watch for missed periods). Oral estrogen blunts IGF-1.

Dilution calculator

Set to the guide's typical mix for GHRP-2. Change anything to see where to draw.

Vial size

BAC water added

Dose you want

Draw to

4u

Volume

0.04 mL

Strength

5 mg/mL

Doses per vial

25

Assumes a U-100 insulin syringe (100 units = 1 mL). Double-check against the compound's page before you draw.

Recommended mixes

Vial	Water	Strength
5 mg	1 mL	5 mg/mL
10 mg	2 mL	5 mg/mL
15 mg	3 mL	5 mg/mL

5 mg: 1 unit = 0.05 mg (50 mcg)

Storage

PowderFreeze-dried: -4°F.
MixedReconstituted: 36–46°F, up to 6 weeks.

Don't use if: Active malignancy of any kind (GH/IGF-1 can promote tumor growth) · Severe diabetic retinopathy · Acute critical illness (per somatropin label) · Pregnancy and lactation

Stop if you notice

Fasting glucose rises >20 mg/dL above baseline
IGF-1 above upper limit of normal for age
New persistent joint pain or carpal tunnel symptoms
Galactorrhea or persistent prolactin symptoms; vision changes

Side effects

Flushing/warmth, mild appetite increase, water retention, occasional prolactin/cortisol bump (rarely tingling nipples). Less hunger than GHRP-6.

Drug interactions

Glucocorticoids: blunt GH response, time away from injection. Insulin / antidiabetics: GH worsens insulin resistance, monitor glucose. Levothyroxine: GH lowers free T4, recheck TSH/fT4 quarterly. Oral estrogens: blunt GH-stimulated IGF-1; dopamine agonists may offset prolactin rise.

Labs

IGF-1 (baseline + Week 8 + end). Target upper-normal for age. Fasting glucose / HbA1c (baseline + end). Prolactin if symptomatic (galactorrhea, low libido). Age-appropriate cancer screening before starting. Out of range? IGF-1 above your age range = too much growth signal (feeds hidden cancer, enlarges organs) → drop the dose; rising glucose/HbA1c = sugar creeping up.

What these labs mean →

Warnings

Insulin resistance / worsening glycemic control with sustained use. Cortisol and prolactin elevation (more than Ipamorelin), keep doses near the saturating ~1 mcg/kg. Fluid retention, carpal tunnel, joint pain with extended use. IGF-1 elevation: theoretical malignancy promotion beyond physiological ranges. Combined GHRH+GHRP use requires off cycles to prevent desensitization.

Patient education

Stimulates your own GH, effects build over weeks. Keep doses near the saturating range; more is not better and raises cortisol/prolactin. Fasted dosing; protect sleep, the largest pulse is at night. Not for use during active malignancy or pregnancy; report new lumps or vision changes.

These apply on top of the universal safety rules.

Pairs well with

CJC-1295 (No DAC) / Sermorelin

canonical GHRH + GHRP synergy

CJC-1295 (No DAC) Sermorelin

Ipamorelin

alternate cleaner GHRP

Ipamorelin

Wolverine Blend

BPC-157 + TB-500

Wolverine Blend

Avoid with

Active malignancy

Severe insulin resistance

Elevated baseline prolactin

Stacking multiple GHRPs at once

Can GHRP-2 + CJC-1295 (No DAC) share a syringe?

Mix freely: the classic GH pair. One GHRH primes the pituitary and one GHRP triggers a bigger pulse. Same solvent, pre-bed, empty stomach.

What it does

Somatropin (HGH) is approved for growth-hormone deficiency and tesamorelin (Egrifta) for HIV lipodystrophy. Secretagogues like this one are off-label.

GHRP-2 (pralmorelin) is a ghrelin-mimetic GH secretagogue (GHS-R1a agonist). It amplifies the GH pulse and, combined with a GHRH analog, produces a markedly larger release than either alone. Mildly raises cortisol and prolactin and stimulates appetite, less than GHRP-6, more than Ipamorelin.

Saturation

Dose plateaus ~1 mcg/kg; going higher mostly adds cortisol/prolactin.

References

researchdosing peptidedosages PubMed thepeptidereport Span 2000 Weissberger 1991

From the guide, page 35.