PEG-MGF protocol · PepGuide

Check your units. The units in this table assume 1 mg/mL, but the guide's recommended mix makes 2 mg/mL. If you mix it that way, your units will be different. Use the calculator to get the right draw for your vial.

Standard

Weeks 1–8

20–40u

200–400 mcg · 2–3×/week

SubQ. On training days, dose within 1–2 h post-workout for best effect.

Off

4 weeks

Standard break between blocks.

Phase	How often	Dose	Units	Notes
Weeks 1–8	2–3×/week	200–400 mcg	20–40u	SubQ. On training days, dose within 1–2 h post-workout for best effect.
Off	4 weeks	–	–	Standard break between blocks.

Units column header in the source reads "Units (1 mg/mL)". Complements native MGF (immediate local) with systemic coverage.

Cycle & timing

Cycle: 6–8 weeks on / 4 weeks off.

Timing: The long half-life gives a wide window, post-workout on training days, anytime on rest days. SubQ; no need to inject into a specific muscle.

Where: SubQ, abdomen. Rotate.

What to expect

Improved recovery and incremental hypertrophy support over a training block, with a far more convenient schedule than native MGF.

How much to buy

For 8-wk @ 250 mcg × 3/wk:

3

× 2mg vials

Men & women

Pegylated MGF (longer half-life), like MGF, women may need slightly less. Efficacy contested; avoid in pregnancy.

Dilution calculator

Set to the guide's typical mix for PEG-MGF. Change anything to see where to draw.

Vial size

BAC water added

Dose you want

Draw to

10u

Volume

0.10 mL

Strength

2 mg/mL

Doses per vial

10

Assumes a U-100 insulin syringe (100 units = 1 mL). Double-check against the compound's page before you draw.

Recommended mixes

Vial	Water	Strength
2 mg	1 mL	2 mg/mL

2 mg: 1 unit = 0.02 mg (20 mcg)

Storage

PowderFreeze-dried: -4°F.
MixedReconstituted: 36–46°F, up to 3–4 weeks, away from light.

Don't use if: Active malignancy of any kind (IGF-1 variant, growth-promoting) · Pregnancy and lactation · Hypersensitivity to the peptide

Stop if you notice

New mass or unexplained tissue growth
Persistent injection-site reaction
Pregnancy

Side effects

Usually minimal, mild injection-site reaction. Theoretical IGF-class concerns at high cumulative exposure.

Drug interactions

No well-characterized interactions. Mind cumulative IGF signaling when stacked with GH-axis/IGF peptides.

Labs

IGF-1 if used heavily or stacked. Age-appropriate cancer screening if used long-term. Out of range? If you stack it with GH-axis peptides, IGF-1 above your age range = too much growth signal → back off.

What these labs mean →

Warnings

Efficacy is contested, a rigorous replication (Fornaro 2014) found the MGF peptide had no effect on muscle cells. Treat benefits as unproven. IGF-family growth signaling, theoretical tumor-promotion concern, more relevant with systemic (PEG) exposure. Limited human data; quality varies, request a COA. Cumulative IGF effect if stacked with GH-axis peptides.

Patient education

The PEG coat gives a wide dosing window, far more practical than native MGF. SubQ; doesn't need to go into a specific muscle. Avoid with active cancer due to growth signaling. Report new lumps or persistent injection-site reactions.

These apply on top of the universal safety rules.

Pairs well with

MGF

local + systemic combo

MGF

IGF-1 LR3

CJC-1295 + Ipamorelin

GH-axis recovery

CJC-1295 (No DAC) + Ipamorelin

Wolverine Blend

BPC-157 + TB-500

Wolverine Blend

Avoid with

Active malignancy

IGF-class growth signaling

Pregnancy

Can PEG-MGF + MGF share a syringe?

Compatible, but check the timing. IGF-1 / MGF / HGH are water-based and compatible. They're often timed post-workout, so you may separate them for timing, not safety.

What it does

PEG-MGF is pegylated Mechano Growth Factor. The PEG coat resists breakdown, extending half-life to ~48–72 hours and allowing systemic satellite-cell activation and recovery support with convenient SubQ dosing 2–3×/week.

References

researchdosing peptidedosages PubMed thepeptidereport

From the guide, page 74.